Dr. Burián Katalin

Email: burian.katalin@med.u-szeged.hu

Phone: +36 62 545-116

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Research projects

We are investigating the members of the Chlamydiaceae family;especially Chlamydophila pneumoniae and the Chlamydia trachomatis infections are examined in vitro and in vivo.

Chlamydiae are special Gram-negative intracellular bacteria with characteristic biphasic lifecycle. Chlamydophila pneumoniae is supposed to be responsible for the 10% of community acquired pneumonia cases. Chlamydia trachomatis is a rather insidious pathogen. It is the most common bacterial pathogen among the sexually transmitted diseases. Unfortunately 70 % of cases caused by Chlamydia trachomatis is asymptomatic in female, thus in the absence of treatment the bacterium can easily spread to the fallopian tube causing its chronic inflammation. The prolonged inflammation can culminate into fibrosis, infertility, and ectopic pregnancy.

- We investigate the immunogenicity and the protective capacity of selected Chlamydia trachomatis proteins in a mouse model.

- Our other aim is to clarify the role of vitamin D treatment during Chlamydophila pneumoniae infection in mice.

- Our third topic is the analysis of the host gene expression in concomitant Chlamydia trachomatis and herpes simplex genitalis infection in in vitro model.

- Furthermore we investigate the characteristics of the innate and adaptive immune response after Chlamydophila pneumoniae infection in mice.

Selected publications:

Mosolygó T, Faludi I, Balogh EP, Szabó AM, Karai A, Kerekes F, Virók DP, Endrész V, Burián K
Expression of Chlamydia muridarum plasmid genes and immunogenicity of pGP3 and pGP4 in different mouse strains. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY 304:(3-4) pp. 476-483. (2014) IF: 3.420

Mosolygo T, Szabo AM, Balogh EP, Faludi I, Virok DP, Endresz V, Samu A, Krenacs T, Burian K
Protection promoted by pGP3 or pGP4 against Chlamydia muridarum is mediated by CD4 cells in C57BL/6N mice. VACCINE 32:(40) pp. 5228-5233. (2014) IF: 3.485

Mosolygó T, Spengler G, Endrész V, Laczi K, Perei K, Burián K
IL-17E Production Is Elevated in the Lungs of Balb/c Mice in the Later Stages of Chlamydia muridarum Infection and Re-infection. IN VIVO 27:(6) pp. 787-792. (2013) IF: 1.148

Mosolygó Tímea, József Korcsik, Balogh Emese Petra, Faludi Ildikó, Virók Dezső P, Endrész Valéria, Burián Katalin
Chlamydophila pneumoniae re-infection triggers the production of IL-17A and IL-17E, important regulators of airway inflammation INFLAMMATION RESEARCH 62:(5) pp. 451-460. (2013) IF: 2.143

Emese P Balogh, Ildikó Faludi, Dezső P Virók, Valéria Endrész, Katalin Burián
Chlamydophila pneumoniae induces production of the defensin-like MIG/CXCL9, which has in vitro anti-chlamydial activity INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY 301:(3) pp. 252-259. (2011) IF: 4.173

Katalin Burian, Valeria Endresz, Judit Deak, Zsolt Kormanyos, Attila Pal, David Nelson, Dezso P Virok
Transcriptome Analysis Indicates an Enhanced Activation of Adaptive and Innate Immunity by Chlamydia-Infected Murine Epithelial Cells Treated with Interferon ? JOURNAL OF INFECTIOUS DISEASES 202:(9) pp. 1405-1414. (2010) IF: 6.288